The Protein Protocols Handbook (Methods in Molecular Biology)

This greatly enhanced second edition introduces 60 critically important new chapters dealing with topics and techniques that have emerged since the first edition, as well as significantly updating the remaining articles. The new chapters cover many rapidly developing areas, particularly the application of mass spectrometry in protein characterization, as well as the now well-established 2-D PAGE technique in proteomics. The section on glycoprotein analysis has also been significantly expanded, and methods for the production of single-chain and phage-displayed antibodies have been added to the section on antibodies. Each readily reproducible method follows the highly praised format of the Methods in Molecular Biology™ series, offering a concise summary of its basic theory, a complete materials list, a step-by-step protocol for its successful execution, and extensive notes on avoiding pitfalls and on modifying the method to function within your own experimental circumstances.

                                

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Drug Targeting Organ-Specific Strategies Hardcover – January 15, 2001 by Grietje Molema (

How are medicines transported intact through the body to their specific target sites without triggering side effects? The answer is "Drug Targeting".

This thoroughly application-oriented book gives comprehensive answers to this and many other questions that confront scientists daily in chemical, pharmaceutical and medical research. A concise overview of the most important basic theories, modern forms of therapy and molecular biological tools, it represents a comprehensible introduction to the topic. The book then goes on to deal with strategies for target applications, divided according to target site, for example brain, lungs, liver, blood vessels and tumor cells. The third part is devoted to special, modern techniques, from phage display methods, via the use of tissue slices right up to pharmacokinetic modeling. Throughout, the focus remains on the practical aspect and successful application of the method in question, although a glance at what the future holds is also included. A volume that every pharmaceutically oriented research group should own

                                      

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Drug Delivery Systems (Methods in Molecular Biology)

In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular Biology™ series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

                                                    

                                               

     

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Drug Delivery: Principles and Applications

An indispensable tool for those working at the front lines of new drug development
Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery.
Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures.
Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key fundamentals, such as physiochemical and biological barriers; drug delivery pathways; metabolism; drug formulation; pharmacokinetic and pharmacodynamic issues; and more. The remainder of the book is devoted to the systematic examination-including overviews, timely examples, and extensive references-of a host of specific subjects, including:
* Receptor-mediated drug delivery
* Prodrug delivery approaches
* Oral protein and peptide drug delivery
* Gene therapy and gene delivery
* Ultrasound-mediated drug delivery
* Polycationic peptides and proteins in drug delivery
* Pulmonary drug delivery
* Antibody-directed drug delivery
* Efflux transporters in drug excretion
* Intellectual property issues in drug delivery


                                


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Drug Transporters: Molecular Characterization and Role in Drug Disposition (Wiley Series in Drug Discovery and Development)

This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport,  in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development.

• Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters
• Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery
• Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials
• Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for novice and expert readers

                                                      

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Drug Delivery and Targeting: For Pharmacists and Pharmaceutical Scientists

                   

The advances in biotechnology and molecular biology over recent years have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of disease. However, such potential is severely compromised by significant obstacles to delivery of these drugs in vivo. These obstacles are often so great that effective drug delivery and targeting is now recognized as the key to effective development of many therapeutics. Advanced drug delivery and targeting can offer significant advantages to conventional drugs, such as increased efficiency, convenience, and the potential for line extensions and market expansion. An accessible and easy-to-read textbook, Drug Delivery and Targeting for Pharmacists and Pharmaceutical Scientists is the first book to provide a comprehensive introduction to the principles of advanced drug delivery and targeting, their current applications and potential future developments, including:

*Methods to optimize therapeutic efficacy, and the related commercial implications

*Difficulties with drug absorption, unwanted distribution and premature inactivation / elimination

*Attempts to minimize toxicity or alter immunogenicity

*Methods to achieve rate-controlled drug release and effective drug targeting

*Novel and established routes of delivery 

*Use of new generation technologies such as biosensors, microchips, stimuli-sensitive hydrogels and plasmid-based gene therapy

This volume is indispensable for pharmaceutical students, scientists and researchers.

                            

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Design of Controlled Release Drug Delivery Systems McGraw-Hill

This is a rigorous exploration of the state of the art in controlled release drug delivery. Written by an International team of experts, this comprehensive text offers pharmaceutical scientists and engineers working in the field, state-of-the-art design principles for the development and bioengineering of drug delivery systems/technology. Readers will find drug delivery systems presented with a particular emphasis on the design principles and their physiological/pathological basis.For each specific design principle, the contributors briefly introduce the relevant pharmacokinetics (where necessary) and include the challenges of different biological barriers that need to be overcome. This in-depth text features detailed coverage of: physiological and biochemical barriers to drug delivery; pharmacokinetics and pharmacodynamics of drug delivery; diffusion and dissolution strategies; rodrugs Bioadhesive and gastric retentive systems; physiological and biochemical barriers to drug delivery; targeted drug delivery; device controlled and programmable drug delivery; and, more.A comprehensive reference on the biochemical, physical, and technical aspects of drug delivery systems, this title includes:; Pharmacokinetics and Pharmacodynamics - Applications in the Design of Controlled Release Drug Delivery Systems; Barriers to Drug Delivery: Physiological and Biochemical Aspects; Prodrugs as Delivery Systems; Diffusion Controlled Systems; Dissolution Controlled Systems; Osmotic Controlled Systems; Biodegradable Polymeric Delivery Systems; Gastric Retention Retentive Dosage Forms; Device Controlled Delivery of Powders; Physical Targeting of Approaches for Drug Delivery; Ligand Based Drug Targeting Approaches for Drug Delivery; Programmable Drug Delivery Systems; and, Carrier and Vector Mediated Delivery Systems for Biological Macromolecules.

                                               

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